That's not all, this is a major release which requires NET 6. There's a new License Manager too 😉.
... but there will be workarounds.
A new start page and a Learn Page.
Geoprocessing tools will display an information tip letting you know when a selection or other filter is applied to input layers and the number of records that will be processed. You will also see tool parameter memory and autofill for commonly used tools accessed from the ribbon and context menus.
Color Vision Deficiency Simulator.
Then there is SAR toolset, Neo4S support to link charts and data from NoSQL, support more CAD and BIM formats etc.